daf-7 Antibody

Code CSB-PA311270XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans daf-7 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
daf-7 antibody; B0412.2 antibody; Dauer larva development regulatory growth factor daf-7 antibody; Abnormal dauer formation protein 7 antibody
Raised in
Species Reactivity
Caenorhabditis elegans
Recombinant Caenorhabditis elegans daf-7 protein
Immunogen Species
Caenorhabditis elegans
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Under harsh environmental conditions, larvae enter a developmentally arrested state known as dauer; TGF-beta-like daf-7 acts to inhibit dauer larva formation and promote growth. May be a ligand to cell surface receptor daf-4. May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family.
Gene References into Functions
  1. DAF-7 expression decreases as animals age during adulthood. Age-dependent diminished expression contributes to the reduced sensitivity of aging animals to the effects of dietary restriction. PMID: 28107363
  2. Using functional, fluorescently-tagged protein, we find that, in animals with mutant DAF-28/IGF, the wild-type DAF-7/TGF-beta is mislocalized to and accumulates in the proximal axon of the ASI neuron. Activation of two different branches of the unfolded protein response can modulate both the developmental phenotype and DAF-7 mislocalization in DAF-28(R37C) animals, but appear to act through divergent mechanisms PMID: 27926939
  3. GLR-1 protein and glr-1 transcription are increased in neurons of DAF-7 mutants. PMID: 26054666
  4. daf-7 has a role in larval development and specifically affects molting and excretory canal development PMID: 23526825
  5. We show that aggregation and bordering are genetically complex, with multiple contributing quantitative trait loci (QTLs), and refine one QTL to identify a new gene affecting the daf-7 pathway, the GABA receptor EXP-1. PMID: 23284308

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Subcellular Location
Protein Families
TGF-beta family
Tissue Specificity
Expression in the chemosensory neurons.
Database Links

KEGG: cel:CELE_B0412.2

STRING: 6239.B0412.2

UniGene: Cel.19630

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