||RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts.
|Gene References into Functions
- Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl, in the zebrafish embryo have been presented. PMID: 26528729
- that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein. PMID: 21695151
- DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish PMID: 19838299
- Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates. PMID: 12296827
||RRM DAZ family
||Testis and ovary specific. In ovary, it is localized in the cortex of oocytes. At the onset of embryogenesis, maternal product is located at the vegetal pole, before migrating toward blastomeres through cytoplasmic streams as early embryogenesis proceeded