DDIT4 Antibody

Datasheet
Code CSB-PA763083XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q7T346
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) DDIT4 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias DNA damage-inducible transcript 4 protein ddit4 zgc:64114
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names ddit4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (By similarity).
Subcellular Location Cytoplasm, Mitochondrion
Protein Families DDIT4 family
Database Links

KEGG: dre:378866

STRING: 7955.ENSDARP00000054787

UniGene: Dr.82488

Pathway mTOR signaling pathway
PI3K-Akt signaling pathway
Autophagy

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