DNM1 Antibody

1. A double deletion mutant in which two essential components of the fission and fusion machinery, Dnm1 and Mgm1, are simultaneously ablated are characterized by impaired respiration and a decrease in mitophagy and replicative lifespan PMID: 25601284
2. the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1 PMID: 23148233
3. The de novo synthesis of peroxisomes is independent of the GTPases Vps1p and Dnm1p, two proteins required for peroxisome fission. PMID: 20655617
4. Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. PMID: 21149566
5. Recruitment of Dnm1p to mitochondria is disrupted in mdv1delta caf4delta yeast, demonstrating that Mdv1p and Caf4p are molecular adaptors that recruit Dnm1p to mitochondrial fission sites PMID: 16009724
6. dynamic interactions between Mdv1 and Dnm1 play a key role in division by regulating Dnm1 self-assembly PMID: 16272155
7. Dnm1p dimers are initially recruited to the membrane via interaction with Mdv1p.Fis1p complexes PMID: 16601120
8. Data suggest that Caf4p and Fis1, but not Mdv1, play a role in determining the polarized localization of those Dnm1p clusters that are not immediately involved in the mitochondrial fission process. PMID: 16835275
9. Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. PMID: 16968746
10. We demonstrate that the dynamin-related protein 1 (Dnm1p), a mitochondrial fission protein conserved from yeast to humans, affects ageing in the two model systems we studied, Podospora anserina and Saccharomyces cerevisiae. PMID: 17173038
11. Thus, our studies have revealed an additional role for Dnm1p in mitochondrial transmission through its interaction with Num1p, thereby providing a link between mitochondrial division and inheritance. PMID: 17336903
12. the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted PMID: 17884824
13. Woronin bodies emerge after the formation of a HEX1 core crystal within peroxisomes followed by Vps1p- and Dnm1p-mediated fission PMID: 18435762
14. findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p PMID: 18445678
15. Mdv1 played a postmitochondrial targeting role in division by interacting & coassembling with the GTP-bound form of Dnm1; this regulated interaction nucleated & promoted self-assembly of Dnm1 into helical structures which drive membrane scission PMID: 19679814

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KEGG: sce:YLL001W

STRING: 4932.YLL001W