DNM1

DNM1 encodes the Dynamin-1 protein, also commonly known as DNM or Dynamin I. Dynamin-1 is a large GTPase involved in endocytosis. It functions by assembling around the neck of budding vesicles and hydrolyzing GTP, leading to membrane fission and vesicle release. It is mainly associated with clathrin - mediated endocytosis pathways.
Mutations in DNM1 have been linked to epileptic encephalopathy. In drug development, research is focused on targeting Dynamin-1's GTPase activity to modulate endocytosis in relevant diseases. Understanding its role could provide new therapeutic strategies for treating related neurological disorders.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007078HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DNM1L.

DNM1L Antibody (CSB-PA007078EA01HU)

Validated Data

Western Blot
Positive WB detected in: A549 whole cell lysate, Mouse heart tissue
All lanes: DNM1L antibody at 0.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 82, 81, 80, 79, 84, 61, 83 kDa
Observed band size: 82 kDa

Immunohistochemistry analysis of human cervical cancer using CSB-PA007078EA01HU at dilution of 1:100

Immunohistochemistry analysis of human brain tissue using CSB-PA007078EA01HU at dilution of 1:100

The following DNM1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

DNM1 Antibodies

DNM1 Proteins

DNM1 Antibodies

DNM1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA007062GA01HU	DNM1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA007078GA01HU	DNM1L Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA007062LA01HU	DNM1 Antibody	Human	ELISA, IHC, IF
CSB-PA051297	DNM1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA058486	Phospho-DNM1 (Ser774) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA297783	Phospho-DNM1L (Ser637) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA825071	DNM1L (Ab-637) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA138782	Phospho-DNM1 (Ser778) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA002203	DNM1L Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA002221	DNM1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA006377	Phospho-DNM1L (S637) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA007806	Phospho-DNM1 (S778) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA007807	Phospho-DNM1 (S774) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA007808	DNM1 Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA617795	DNM1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA448541	DNM1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA007078EA01HU	DNM1L Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA007078EB01HU	DNM1L Antibody, HRP conjugated	Human	ELISA

DNM1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA345810XA01SVG	DNM1 Antibody	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	ELISA, WB (ensure identification of antigen)

DNM1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA601029XA01SXV	dnm1 Antibody	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ELISA, WB (ensure identification of antigen)

DNM1 Proteins

DNM1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-EP007062HU	Recombinant Human Dynamin-1 (DNM1), partial	E.coli
CSB-YP007078HU CSB-BP007078HU CSB-MP007078HU CSB-EP007078HU-B	Recombinant Human Dynamin-1-like protein (DNM1L)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP007062HU	Recombinant Human Dynamin-1 (DNM1), partial	Yeast
CSB-EP007078HU	Recombinant Human Dynamin-1-like protein (DNM1L)	E.coli
CSB-BP007062HU CSB-MP007062HU CSB-EP007062HU-B	Recombinant Human Dynamin-1 (DNM1), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP007062HUa0	Recombinant Human Dynamin-1 (DNM1), partial	E.coli

DNM1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP007062RA CSB-EP007062RA CSB-BP007062RA CSB-MP007062RA CSB-EP007062RA-B	Recombinant Rat Dynamin-1 (Dnm1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DNM1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP007062MO CSB-EP007062MO CSB-BP007062MO CSB-MP007062MO CSB-EP007062MO-B	Recombinant Mouse Dynamin-1 (Dnm1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DNM1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Source
CSB-YP345810SVG CSB-EP345810SVG CSB-BP345810SVG CSB-MP345810SVG CSB-EP345810SVG-B	Recombinant Saccharomyces cerevisiae Dynamin-related protein DNM1 (DNM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DNM1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Source
CSB-YP601029SXV CSB-EP601029SXV CSB-BP601029SXV CSB-MP601029SXV CSB-EP601029SXV-B	Recombinant Schizosaccharomyces pombe Dynamin-like protein C12C2.08 (SPBC12C2.08), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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DNM1

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