EBNA3 Antibody

Code CSB-PA319032ZA01EFA
Size US$299
Image
  • Western Blot
    Positive WB detected in Recombinant protein
    All lanes: EBNA3 antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 22.2 kDa
    Observed band size: 33 kDa
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Product Details

Uniprot No.
Target Names
EBNA3
Alternative Names
Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) (EBNA-3A) (EBV nuclear antigen 3A), EBNA3
Species Reactivity
Epstein-Barr virus
Immunogen
Recombinant Epstein-Barr virus EBNA3 protein (1-138aa)
Immunogen Species
Epstein-Barr virus
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The development of the EBNA3 polyclonal antibody follows a well-defined procedure. It initiates with the repeated immunization of a rabbit using recombinant Epstein-Barr virus EBNA3 protein (1-138aa), continuing until an optimal antibody titer is achieved. Subsequently, the rabbit's blood is collected, and the antibodies are purified from the serum using protein G. The functionality of the resulting EBNA3 antibody is comprehensively assessed in ELISA and WB applications, affirming its specific binding with the Epstein-Barr virus EBNA3 protein.

The Epstein-Barr virus (EBV) EBNA3 proteins (EBNA3A, EBNA3B, and EBNA3C) play a crucial role in the regulation of viral gene expression and the transformation of B lymphocytes. They are involved in the modulation of host gene expression, cell cycle control, and immune evasion. EBNA3A and EBNA3C, in particular, contribute to maintaining the immortalization of infected B cells by inhibiting the function of certain tumor suppressor proteins.

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Target Background

Function
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
Gene References into Functions
  1. the polycomb repressor complex is essential for EBNA3A-mediated repression of STK39 Findings in this study provide new insights into the regulation of cellular genes by the transcription factor EBNA3A. PMID: 29367247
  2. These results indicate that EBNA3 proteins interact with multiple RBP/CSL domains, but only N-terminal domain interactions are required for lymphoblastoid cell line growth. PMID: 21440926
  3. EBNA-3 plays a role in facilitating the ligand-dependent AhR activation process PMID: 16257957
Subcellular Location
Host nucleus matrix. Note=Associated with the nuclear matrix.
Protein Families
Herpesviridae EBNA-3 family
Database Links

KEGG: vg:3783762

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