ENGASE Antibody

1. In patients with autosomal dominant polycystic kidney disease, urinary NAGase was correlated with urinary ET-1 which was inversely associated with eGFR and positively correlated with total kidney volume. PMID: 26923419
2. Serological N-acetyl-glucosaminidase, telomere length, and the UCP2-886G>A variant are independent risk factors for type 2 diabetes. PMID: 21873561
3. O-GlcNAcase expression is increased in erythrocytes from both individuals with pre-diabetes and individuals with less well-controlled diabetes. PMID: 20413512
4. Data show that kinetic and X-ray crystallographic analyses of the binding modes with human/bacterial O-GlcNAcases identify some of these as competitive inhibitors. PMID: 20026047
5. involved in processing of free oligosaccharides in the cytosol; identification of the gene encoding human cytosolic ENGase PMID: 12114544
6. endo-beta-n-acetylglucosaminidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing the invasion of synovial cells PMID: 12905469
7. identification of O-GlcNAcase as a caspase-3 substrate with a novel caspase-3 cleavage site and provide insight about O-GlcNAcase regulation during apoptosis. PMID: 18586680

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HGNC: 24622

OMIM: 611898

KEGG: hsa:64772

STRING: 9606.ENSP00000462333

UniGene: Hs.29288