ENGASE Antibody

Code CSB-PA854117ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ENGASE Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Cytosolic endo-beta-N-acetylglucosaminidase antibody; DKFZp434P174 antibody; ENASE_HUMAN antibody; ENGase antibody; FLJ21865 antibody; Mannosyl glycoprotein endo beta N acetylglucosaminidase antibody
Raised in
Species Reactivity
Homo sapiens
Recombinant Homo sapiens ENGASE protein
Immunogen Species
Homo sapiens (Human)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
Gene References into Functions
  1. In patients with autosomal dominant polycystic kidney disease, urinary NAGase was correlated with urinary ET-1 which was inversely associated with eGFR and positively correlated with total kidney volume. PMID: 26923419
  2. Serological N-acetyl-glucosaminidase, telomere length, and the UCP2-886G>A variant are independent risk factors for type 2 diabetes. PMID: 21873561
  3. O-GlcNAcase expression is increased in erythrocytes from both individuals with pre-diabetes and individuals with less well-controlled diabetes. PMID: 20413512
  4. Data show that kinetic and X-ray crystallographic analyses of the binding modes with human/bacterial O-GlcNAcases identify some of these as competitive inhibitors. PMID: 20026047
  5. involved in processing of free oligosaccharides in the cytosol; identification of the gene encoding human cytosolic ENGase PMID: 12114544
  6. endo-beta-n-acetylglucosaminidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing the invasion of synovial cells PMID: 12905469
  7. identification of O-GlcNAcase as a caspase-3 substrate with a novel caspase-3 cleavage site and provide insight about O-GlcNAcase regulation during apoptosis. PMID: 18586680

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Subcellular Location
Cytoplasm, cytosol.
Protein Families
Glycosyl hydrolase 85 family
Tissue Specificity
Widely expressed. Expressed at higher level in thymus and spleen.
Database Links

HGNC: 24622

OMIM: 611898

KEGG: hsa:64772

STRING: 9606.ENSP00000462333

UniGene: Hs.29288

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