EPHA3 Antibody

Datasheet
Code CSB-PA007723XA01DIL
Product Type Polyclonal Antibody
Uniprot No. O13146
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) EPHA3 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 1) (Tyrosine-protein kinase receptor ZEK1) epha3 ek1 zek1
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names epha3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation probably through activation by efna1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity).
Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Tissue Specificity Widely expressed in the developing zebrafish nervous system.
Database Links

KEGG: dre:30311

STRING: 7955.ENSDARP00000096552

UniGene: Dr.75760

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