EPHB3 Antibody

Datasheet
Code CSB-PA007731XA01DIL
Product Type Polyclonal Antibody
Uniprot No. O13147
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) EPHB3 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like kinase 3) (Tyrosine-protein kinase receptor ZEK3) (Fragment) ephb3 ek3 zek3
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names ephb3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. May control other aspects of development through regulation of cell migration and positioning (By similarity). May play a role in early pattern formation within the developing nervous system.
Subcellular Location Cell membrane, Single-pass type I membrane protein, Cell projection, dendrite
Protein Families Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Tissue Specificity Widely expressed in the developing nervous system.
Database Links

UniGene: Dr.28327

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