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| Code | CSB-PA008645XA01DIL |
| Product Type | Polyclonal Antibody |
| Uniprot No. | Q8JG38 |
| Delivery | Make-to-order |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) FGFR2 protein |
| Raised in | Rabbit |
| Species Reactivity | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method | Protein A/G |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) fgfr2 |
| Immunogen Species | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Gene Names | fgfr2 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity). |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, Golgi apparatus, Cytoplasmic vesicle |
| Protein Families | Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily |
| Database Links |
STRING: 7955.ENSDARP00000124761 UniGene: Dr.116399 |
| Pathway |
MAPK signaling pathway
PI3K-Akt signaling pathway Regulation of actin cytoskeleton Ras signaling pathway Signaling pathways regulating pluripotency of stem cells Rap1 signaling pathway Endocytosis |
fgfr2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP008645DIL CSB-EP008645DIL CSB-BP008645DIL CSB-MP008645DIL |
Recombinant Danio rerio Fibroblast growth factor receptor 2(fgfr2),partial | Yeast E.coli Baculovirus Mammalian cell |
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