FOXN4 Antibody

Datasheet
Code CSB-PA850403XA01HU
Product Type Polyclonal Antibody
Uniprot No. Q96NZ1
Delivery Make-to-order
Immunogen Recombinant Homo sapiens (Human) FOXN4 protein
Raised in Rabbit
Species Reactivity Homo sapiens (Human)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Forkhead box protein N4 FOXN4
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Gene Names FOXN4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).
Subcellular Location Nucleus
Database Links

HGNC: 21399

OMIM: 609429

KEGG: hsa:121643

STRING: 9606.ENSP00000299162

UniGene: Hs.528316

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