Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) GAPC1 Polyclonal antibody

Uniprot No.

P25858

Target Names

GAPC1

Alternative Names

GAPC1 antibody; GAPC antibody; GAPDH antibody; At3g04120 antibody; T6K12.26Glyceraldehyde-3-phosphate dehydrogenase GAPC1 antibody; cytosolic antibody; EC 1.2.1.12 antibody; NAD-dependent glyceraldehydephosphate dehydrogenase C subunit 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana GAPC1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to the outer mitochondrial membrane, in a redox-dependent manner, leading to binding and bundling of actin. Actin binding and bundling occurs under oxidizing conditions and is reversible under reducing conditions. May be part of a redox-dependent retrograde signal transduction network for adaptation upon oxidative stress. Binds DNA in vitro.

Gene References into Functions

the redox-dependent localization of GapC1 and GapC2 in the different cellular subcompartments and their interactions with VDAC3 and Trx-h3 PMID: 30189844
The E3 ubiquitin-ligase SEVEN IN ABSENTIA like 7 mono-ubiquitinates GAPC1 in vitro and is required for its nuclear localization. PMID: 26582368
After perception of bacterial flagellin, GAPC1 dynamically responded with a significant increase in size of fluorescent puncta and enhanced nuclear accumulation PMID: 25918875
FERONIA controls leaf starch accumulation by interacting with GAPC1. PMID: 26232644
GAPC levels play important roles in the overall cellular production of reductants, energy, and carbohydrate metabolites and that GAPC levels are directly correlated with seed oil accumulation. PMID: 24989043
Glycolytic GAPC1, through its high sensitivity to the cellular redox state, may play a role in oxidative stress signaling or protection in plants. PMID: 23569110
Results indicate that the H(2)O(2)-promoted interaction of GAPC and PLDdelta may provide a direct connection between membrane lipid-based signaling, energy metabolism and growth control in the plant response to ROS and water stress. PMID: 22589465
The addition of GSSG, and much more efficiently of S-nitrosoglutathione, was shown to inactivate the enzymes GapC1 and GapC2 from Arabidopsis thaliana, spinach, yeast and rabbit muscle. [GapC1] PMID: 18298409

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Glyceraldehyde-3-phosphate dehydrogenase family

Tissue Specificity

Expressed in leaves, stems and siliques and at lower levels in roots and flowers.

Database Links

KEGG: ath:AT3G04120

STRING: 3702.AT3G04120.1

UniGene: At.22963

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GAPC1 Antibody

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