Trl Antibody

1. GAF (Vfl) as an additional factor in regulation of early developmental genes. PMID: 28676122
2. GAF interactions with a small subset of partners is direct; however for many others the interactions could be indirect, and depend upon intermediates that serve to diversify the functional capabilities of the GAF protein PMID: 28296955
3. GAF acts upstream of promoter-proximally paused RNA polymerase II (Pol II) formation (likely at the step of chromatin opening) and that GAF-facilitated Pol II pausing is critical for HS activation PMID: 27492368
4. The regulatory region of the Trl gene was analyzed using the mutation Trl (3609), resulting from the insertion of the P-element into the promoter region of the gene as well as mutations obtained on its basis; two last transcription start sites, which are most often used in vitro in S2 cells, are almost not used in vivo; transcription terminators in transposons play an important role in decreasing transcription PMID: 28058687
5. Expression pattern of the Trl gene suggests its activity in epithelial cells of the embryonic blastoderm, part of which contact primordial cells. Thus, GAGA factor influences migration of these cells in an indirect manner via their somatic environment. PMID: 27149747
6. Pleiotropic mutation effects can be explained by the misexpression of GAGA factor target genes, the products of which are required for germ cell progression into mature sperm. PMID: 24817547
7. prion-like behavior of the GAF Q domain PMID: 23731888
8. The second intron of the Trl gene contains functionally significant elements. PMID: 23481306
9. GAF is required for the full activation of target genes by dE2f1 and Yki/Sd; while ablation of GAF compromises both normal and inappropriate cell proliferation driven by Yki and dE2f1 in multiple tissues. PMID: 23070566
10. compilation of the presently largest sample (120 sites) of published nucleotide sequences with experimentally confirmed binding to GAGA protein PMID: 22099633
11. The GAGA protein is essential for dorsal appendage formation during Drosophila melanogaster oogenesis. PMID: 21369899
12. Data show that the Evx2-Hoxd13 boundary activity in Drosophila is dependent on GAGA factor that binds to the GA repeat motif. PMID: 21098566
13. Lysine residues K325 and K373 on basic regions BR1 and BR3 of the DNA binding domain, respectively, are shown to be acetylated by PCAF PMID: 20849112
14. We surveyed the current scientific literature for evidence of GAF involvement in regulatory events associated with changes of chromatin composition or conformation. PMID: 16936828
15. GAGA factor associates with 39% of the genes that have NELF. Surprisingly, NELF associates with almost one-half of the most highly expressed genes, indicating that NELF is not necessarily a repressor of gene expression. PMID: 18332113

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KEGG: dme:Dmel_CG33261

UniGene: Dm.7610