HDAC1 Antibody

Datasheet

Code	CSB-PA213658XA01OFG
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Oryza sativa subsp. japonica (Rice) HDAC1 Polyclonal antibody

Uniprot No.

Q7Y0Y8

Target Names

HDAC1

Alternative Names

HDAC1 antibody; HDA702 antibody; Os06g0583400 antibody; LOC_Os06g38470 antibody; P0498C03.28-1 antibody; Histone deacetylase 1 antibody; OsHDAC1 antibody; EC 3.5.1.98 antibody

Raised in

Rabbit

Species Reactivity

Oryza sativa subsp. japonica (Rice)

Immunogen

Recombinant Oryza sativa subsp. japonica (Rice) HDAC1 protein

Immunogen Species

Oryza sativa subsp. japonica (Rice)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (Probable). Regulates negatively the expression of the NAC48/NAC6 gene that controls root growth in seedlings. Epigenetically represses the expression of NAC48/NAC6 by deacetylating 'Lys-9' (H3K9ac), 'Lys-14' (H3K14ac) and 'Lys-18' (H3K18ac) of histone H3, and 'Lys-5' (H4K5ac), 'Lys-12' (H4K12ac) and 'Lys-16' (H4K16ac) of histone H4. Functions in the regulation of gene expression in the whole genome. Acts as chromatin remodeling regulator to promote the formation of a repressive chromatin state. Functions with MODD via its interaction with TPR3, to down-regulates the histone acetylation level at BZIP46 target genes. BZIP46 is a positive regulator of abscisic acid (ABA) signaling and drought stress tolerance.

Gene References into Functions

OsHDAC1 epigenetically regulates the OsNAC6 gene, and that this is primarily responsible for the alteration of root development in rice seedlings. PMID: 19453457

Subcellular Location

Nucleus.

Protein Families

Histone deacetylase family, HD Type 1 subfamily

Tissue Specificity

Expressed in roots and leaves.

Database Links

KEGG: osa:4341387

STRING: 39947.LOC_Os06g38470.1

UniGene: Os.10708

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Notch signaling pathway Cell cycle

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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