HDAC1

Histone deacetylase 1 is a protein in humans that is encoded by HDAC1 gene. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity.

HDAC1 Antibodies

HDAC1 Antibodies for Homo sapiens (Human)

HDAC1 Antibodies for Human

HDAC1 Antibodies for Oryza sativa subsp. japonica (Rice)

HDAC1 Proteins

HDAC1 Proteins for Gallus gallus (Chicken)

HDAC1 Proteins for Mus musculus (Mouse)

HDAC1 Proteins for Strongylocentrotus purpuratus (Purple sea urchin)

HDAC1 Proteins for Rattus norvegicus (Rat)

HDAC1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

HDAC1 Proteins for Homo sapiens (Human)

HDAC1 Proteins for Bos taurus (Bovine)

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