IZUMO1R Antibody

Datasheet

Code	CSB-PA008789ZA01HU
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) IZUMO1R Polyclonal antibody

Uniprot No.

A6ND01

Target Names

IZUMO1R

Alternative Names

IZUMO1R antibody; FOLR4 antibody; JUNO antibody; Sperm-egg fusion protein Juno antibody; Folate receptor 4 antibody; Folate receptor delta antibody; FR-delta antibody; IZUMO1 receptor protein JUNO antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens

Immunogen

Recombinant Homo sapiens IZUMO1R protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.

Gene References into Functions

Juno single nucleotide polymorphisms associated with fertilization failure and polyspermy after in vitro fertilization in women. PMID: 29243140
JUNO interacts with IZUMO1 during sperm binding. PMID: 27416963
crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction PMID: 27309808
crystal structures of human IZUMO1 and JUNO in unbound and bound conformations PMID: 27309818

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

Folate receptor family

Database Links

HGNC: 32565

OMIM: 615737

KEGG: hsa:390243

STRING: 9606.ENSP00000416935

UniGene: Hs.553758

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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IZUMO1R Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background