Il31ra Antibody

Code CSB-PA818362ZA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Il31ra Polyclonal antibody
Uniprot No.
Target Names
Il31ra
Alternative Names
Il31ra antibody; GlmrInterleukin-31 receptor subunit alpha antibody; IL-31 receptor subunit alpha antibody; IL-31R subunit alpha antibody; IL-31R-alpha antibody; IL-31RA antibody; GLM-R antibody; mGLM-R antibody; Gp130-like monocyte receptor antibody; Gp130-like receptor antibody; Novel cytokine receptor 10 antibody; NR10 antibody; ZcytoR17 antibody
Raised in
Rabbit
Species Reactivity
Mus musculus
Immunogen
Recombinant Mus musculus Il31ra protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
Gene References into Functions
  1. Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice PMID: 24946165
  2. IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch. PMID: 24373353
  3. Gp130(757F/F) mice rapidly develop distal stomach tumors, with loss of SHP2/Erk/AP-1 transcriptional regulation exemplified by decreased TFF1 expression and increased STAT1/3 regulated genes such as Reg I. PMID: 14699500
  4. IL-31 receptor alpha signaling is a novel negative regulatory pathway that specifically limits T helper cell type 2 inflammation. PMID: 17353366
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
Protein Families
Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity
Expressed in a subset of dorsal root ganglia neurons. Expressed in spinal cord and trigeminal ganglion (at protein level). Expressed in skin, testis, bone marrow and thymus.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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