Ins2 Antibody

1. High INS2 expression is associated with weight gain and obesity. PMID: 29122848
2. Data (including data from studies in knockout mice) suggest that Ins2 is involved in impaired nociception/diabetic neuropathy; here, mice heterozygous for mutant Ins2 exhibit (a) significant loss of intra-epidermal nerve fibers, (b) markedly reduced responsiveness to heat in dorsal root ganglion neurons, and (c) mostly unchanged function of cold-sensitive neurons; such mice become diabetic soon after weaning. PMID: 29875100
3. These results suggest that PABP interacts with HuD in basal glucose conditions making translation inhibitory complex, however upon glucose stimulation this association is affected and PABP is acted upon by PDI resulting in stimulation of insulin translation. PMID: 29590218
4. cTAGE5 deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice. PMID: 29133483
5. report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification PMID: 27936229
6. Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development. PMID: 26784909
7. Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus. PMID: 26956881
8. have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(+/Akita) mouse model and present evidence for the action of sex hormones on pancreatic beta-cell function PMID: 26597883
9. Data indicate that insulin/incomplete Freund's adjuvant (IFA) does not prevent but induces diabetes in RIP-CD80GP transgenic mice. PMID: 24387268
10. RORalpha is a transcriptional activator of insulin. PMID: 24583012
11. Mice deficient in coinhibitory PD-L1 or PD-1 molecules (PD-L1(-/-) and PD-1(-/-) mice), were used to study induction of preproinsulin (ppins)-specific CD8 T-cell responses and experimental autoimmune diabetes. PMID: 23977133
12. Akita mouse has a mutation in Ins2 and is a model of the effects of maternal and paternal hyperglycemia in wildtype offspring PMID: 23209676
13. Cortical bone was affected in STZ but not Ins2(+/-) mice. PMID: 22886636
14. proSAAS as a novel down-regulated target of Pax6 PMID: 23056534
15. Leptin administration improves dyslipidemia and reduces atherosclerosis in type 1 diabetic Ins2(+/Akita):apoE(-/-) mice. PMID: 23099119
16. Ins2(Akita) mouse is a good model for later-onset DR, modeling both early and some late disease signs. PMID: 23221078
17. The Akita(ins2) type 1 diabetic model is protected against systolic failure due to increased NCX1 expression via a CXCR4/NF-kappaB pathway. PMID: 22610174
18. Integrin alpha1KOAkitaKO Balb/c mouse represents a promising model presenting with most features of human diabetic nephropathy. PMID: 22297672
19. these results indicate that CaMKIIdelta2 downregulates insulin gene expression by Ser142 phosphorylation of CREB and reducing binding of CREB to CBP. PMID: 22554507
20. HuD controls insulin II translation PMID: 22387028
21. Data show that TMED6 mRNA is highly and selectively expressed in pancreas,and knockdown of TMED6 gene expression in Min6 beta cells decreased insulin secretion. PMID: 22129529
22. The results indicated that intraislet ghrelin does not play a major role in the regulation of insulin secretion in vivo. PMID: 22114024
23. Data suggest that high glucose mediates the recruitment of p300, CBP, PCAF, and GCN5 to the insulin promoter and that all four histone acetyltransferase (HATs) are important for insulin gene expression. PMID: 21774670
24. Raf-1 specifically and acutely regulates insulin 2 mRNA via negative action on Foxo1 PMID: 21817126
25. The findings demonstrate that the perturbation of proinsulin homeostasis results in defects in the subsequent conversion process of proinsulin and is a contributor to the occurrence of disproportionate hyperproinsulinemia in diabetes. PMID: 21723250
26. Exaggerated hypercholesterolemia and atherosclerosis in spontaneously diabetic Ins2(+/Akita):apoE(-/-) mice may be attributable to impaired lipoprotein clearance in the setting of diminished expression of LSR. PMID: 21447785
27. The transcriptional programs in both endoneurial and neuronal compartments of the peripheral nerve are relatively resistant to the onset of hyperglycemia and hypoinsulinemia in Ins2 mice. PMID: 20520806
28. Alternative splicing of insulin mRNA in mice could result in an additional level of regulation in insulin biosynthesis. PMID: 20153322
29. These studies identify strong effects of genetic background to modify the renal phenotype associated with the Ins2(C96Y) mutation. PMID: 20042456
30. Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. PMID: 19801494
31. The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the mouse model of Beckwith-Wiedemann Syndrome. PMID: 19684026
32. mutated in iddm in mice PMID: 11981430
33. findings suggest that the organelle dysfunction resulting from the intracellular accumulation of misfolded proinsulin 2 is primarily responsible for the defect of coexisting wild-type insulin secretion in Akita beta-cells PMID: 12540615
34. Transcriptional up-regulation of the remaining functional insulin gene in Ins2-/- mice could potentially contribute to beta-cell adaptation. PMID: 12745665
35. Wild-type preproinsulin-2-expressing pancreatic islets transplanted in preproinsulin-2-deficient mice elicit a mononuclear cell infiltration and insulin antibodies; graft infiltration is further increased by immunization with preproinsulin-2 peptides. PMID: 14688305
36. A missense mutation of the insulin 2 gene (Cys96Tyr) disrupts 1 of the 2 interchain disulfide bonds resulting in accumulation of misfolded protein in pre-Golgi intermediates. PMID: 15033933
37. platelet-derived growth factor-induced cell proliferation is inhibited by insulin PMID: 15525682
38. Pancreatic beta-cells that glucose stimulates the recruitment of ribosome-associated proinsulin mRNA, located in the cytoplasm, to the ER, the site of proinsulin synthesis; this plays an important role in glucose-stimulated proinsulin synthesis. PMID: 15972000
39. Proinsulin-2 gene expression by radioresistant thymic epithelial cells is involved in the induction of self-tolerance, and additional factors are required to induce islet abnormalities. PMID: 16785498
40. Munich Ins2 mutant mice are a valuable model to study the mechanisms of beta-cell dysfunction and death during development of diabetes. PMID: 17303807
41. diabetes causes fusion between Proins-P bone marrow-derived cells and hepatocytes PMID: 17360472
42. Cre recombinase is controlled by a short fragment of the rat insulin II gene promoter PMID: 17533574
43. The data underline a direct role for Aire in tissue-restricted antigens expression and suggest that modulation of Aire has a potential to control central tolerance and autoimmunity. PMID: 17599412
44. misfolded proinsulin causes enlargement of pre-Golgi intermediates which indicates their involvement in protein quality control. PMID: 17647009
45. Nonobese, insulin-deficient Ins2(Akita) mice develop type 2 diabetes phenotypes including peripheral and hepatic insulin resistance and cardiac remodeling. PMID: 17911348
46. Insulin II is a direct target of RHOX5. PMID: 18184911
47. Arterial superoxide generated from diverse sources may potentiate the contractions of carotid arteries in Ins2(Akita) diabetic mice. PMID: 18788099
48. Mutant huntingtin disrupts intracellular transport and insulin secretion by interacting with tubulin beta 5. PMID: 19628478
49. Ins2 expression by NOD bone marrow-derived cells did not delay diabetes development in NOD-Ins2-/- mice. PMID: 19874548

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KEGG: mmu:16334

STRING: 10090.ENSMUSP00000000220

UniGene: Mm.4946