KCC2B Antibody

Code CSB-PA004466XA01MO
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Camk2b Polyclonal antibody
Uniprot No. P28652
Target Names Camk2b
Alternative Names Camk2b antibody; Camk2d antibody; Calcium/calmodulin-dependent protein kinase type II subunit beta antibody; CaM kinase II subunit beta antibody; CaMK-II subunit beta antibody; EC 2.7.11.17 antibody
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Immunogen Recombinant Mus musculus (Mouse) KCC2B protein
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

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Target Data

Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Gene References into Functions
  1. Region-specific overexpression of betaCaMKII in dentate gyrus (DG) impairs behavioral flexibility, and severely attenuates the NMDAR-dependent long-term depression (LTD) in DG medial perforant path, which is further confirmed by the diminished AMPAR internalization and dephosphorylation during LTD. PMID: 27993520
  2. data suggest that phosphorylation of CaMKIIbeta through the mGluR/IP3R1/PKC signaling pathway represses excessive spine formation and elongation in mature Purkinje cells. PMID: 28607044
  3. The molecular, temporal and region-specific requirements of the CAMK2B in mouse locomotion have been described. PMID: 27244486
  4. Study used an unbiased semiquantitative proteomics approach to identify biologically relevant phosphorylation sites on both CaMKIIa and CaMKIIb PMID: 25650780
  5. CaMKK/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia. PMID: 23868268
  6. Our data point toward a critical role of CaMKIIbeta in regulating oligodendrocyte maturation and CNS myelination via an actin-cytoskeleton-regulatory mechanism PMID: 23785157
  7. Muscle-specific CamkIIss isoform is critical for receptor recycling and may provide a mechanism by which the postsynaptic acetylcholine receptor density is maintained at the neuromuscular junction in vivo. PMID: 20844140
  8. is expressed in motor neurons during axon outgrowth and is part of slow axonal transport. PMID: 11891785
  9. accumulated in the nuclei of brain cells by pentylenetetrazol-mediated seizure via cellular mechanisms other than transcriptional and post-transcriptional regulation PMID: 11897160
  10. Ca/CaMK II activation plays an important role in the transmission of GnRH signals from the plasma membrane to the LH subunit genes. PMID: 12746302
  11. Expression of an active form of CaMKII beta after 1 day of T cell activation enhances initial proliferation and cytotoxic T cell activity, but induces profound unresponsiveness to peptide restimulation. PMID: 15843557
  12. activated CaMKII directly phosphorylated the recombinant COOH-terminal region of FAK at a residue equivalent to Ser-843 PMID: 15845548
  13. CaM kinase IIdelta2 was involved in the GnRH-induced activation of MAP kinase in GT1-7 cells. PMID: 17706588
  14. betaCaMKII activity in the dentate gyrus selectively impaired long-term potentiation in the dentate perforant path, but not in the CA1 Schaffer collateral pathway. PMID: 17913888
  15. We found that betaCaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse PMID: 19503086
  16. Deletion studies indicated three important parts of beta CaM kinase II: beta-specific insertion 2, the association domain, and the oligomeric form; all 3 play an important role in its cellular distribution. PMID: 11532017

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Subcellular Location Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Sarcoplasmic reticulum membrane, Peripheral membrane protein, Cytoplasmic side
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Database Links

KEGG: mmu:12323

UniGene: Mm.439733

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