Klk8 Antibody

1. Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin. PMID: 22520925
2. Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 in the late stages of wound healing. PMID: 22358061
3. KLK8 is involved in synaptic tagging during LTP at basal and apical dendritic inputs. PMID: 21646406
4. the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynamics of the EphB2-NMDA-receptor interaction, the expression of Fkbp5 and anxiety-like behaviour PMID: 21508957
5. Klk8 might thus be involved in tissue development and rearrangement. PMID: 20180635
6. role of loop structures in the activity of serine protease and regulated secretion PMID: 11854276
7. Neuropsin was localized extracellularly in neuronal cell bodies and their neurites in mouse hippocampus. Neuropsin may be involved in neurite outgrowth during the development of the nervous system. PMID: 11880192
8. gene expression of a serine-protease neuropsin in the mouse vagina, and as a marker of the estrogen-independent persistent proliferation and cornification of the vaginal epithelium PMID: 12354676
9. Neuropsin is the first extracellular protease to show the evident induction of expression and activity by decidualization and might contribute to the remodeling of extracellular components after decidualization. PMID: 12390870
10. mouse MCs store at least two distinct families of tryptic-like proteases in their secretory granules, including PRSS19 PMID: 12646205
11. Presynaptic adhesion molecule L1 is a substrate for neuropsin in the hippocampus. PMID: 12944500
12. study demonstrates changes in the expression of neuropsin and protease M/neurosin in oligodendrocytes following hemisection of the spinal cord PMID: 15378660
13. Neuropsin-/- mice showed attenuated demyelination and delayed oligodendroglial death early during the course of autoimmune encephalomyelitis PMID: 15920728
14. Nrpn is necessary for establishment of LTP and has a significant role in memory acquisition. PMID: 16308352
15. These observations suggest that neuropsin is involved in the secondary phase of the pathogenesis of SCI mediated by demyelination, oligodendrocyte death, and axonal degeneration. PMID: 17629414
16. Neuropsin-dependent late associativity is particularly important in nonstressful associative memory. PMID: 18216192
17. Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice. PMID: 18513120

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KEGG: mmu:259277

STRING: 10090.ENSMUSP00000082588

UniGene: Mm.458023