Klra3 Antibody

1. This docking mode was conserved with that previously observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar energetic footprints focused around residues located within the Ly49C beta4-stand and L5 loop, which contact the underside of the peptide-binding platform floor. PMID: 27385590
2. murine cytomegalovirus infection results in altered NK cell activation PMID: 24873973
3. we have shown for the first time how the differential expression of the Ly49 inhibitory receptors during ontogeny can affect NK cell function PMID: 23960238
4. This study showed that mPer2 is a critical clock component in modulating circadian rhythms in bone marrow, and it implies that Ly49C and Nkg2d may play an important role in mediating mPer2-controlled cytotoxic response. PMID: 20030538
5. Three mutations have been introduced in Ly49C that correspond to Ly49A residues close to H-2Dd in the co-crystal, demonstrating that MHC class I binding by Ly49C is dependent on residues in the same area as that used by Ly49A for ligand contacts. PMID: 11777974
6. signaling through the mouse NK inhibitory receptor Ly49C requires the presence of H-2Kb and this signaling is prevented when H-2Kb is ablated by pulsing with a peptide that can bind to it with high affinity PMID: 16148097
7. adoptive infusion of alloreactive NK cells with silenced Ly49C gene results in suppression of graft-versus-host disease PMID: 19010415

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KEGG: mmu:16634

STRING: 10090.ENSMUSP00000085333

UniGene: Mm.425338