LCE3A Antibody

Code CSB-PA716360ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LCE3A Polyclonal antibody
Uniprot No.
Target Names
LCE3A
Alternative Names
LCE3A antibody; LEP13Late cornified envelope protein 3A antibody; Late envelope protein 13 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens LCE3A protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
Gene References into Functions
  1. genetic polymorphism is associated with psoriasis vulgaris among Mongolians from Inner Mongolia PMID: 29397434
  2. analysis of disease variants at the LCE3 cluster among the psoriasis patients in India PMID: 27048876
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19601998
  4. paper describing nomenclature changes and expression in range of tissues and in response to UV PMID: 15854049
Protein Families
LCE family
Tissue Specificity
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
Database Links

HGNC: 29461

OMIM: 612613

KEGG: hsa:353142

STRING: 9606.ENSP00000335006

UniGene: Hs.553714

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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