Recombinant Human Late cornified envelope protein 3A (LCE3A)

Code CSB-YP716360HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP716360HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP716360HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP716360HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
LCE3A
Uniprot No.
Alternative Names
LCE3A; LEP13Late cornified envelope protein 3A; Late envelope protein 13
Species
Homo sapiens (Human)
Expression Region
1-89
Target Protein Sequence
MSCQQNQQQC QPPPKCPAKS PAQCLPPASS SCAPSSGGCG PSSERSCCLS HHRCRRSHRC RCQSSNSCDR GSGQQGGSSS CGHSSAGCC
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
Gene References into Functions
  1. genetic polymorphism is associated with psoriasis vulgaris among Mongolians from Inner Mongolia PMID: 29397434
  2. analysis of disease variants at the LCE3 cluster among the psoriasis patients in India PMID: 27048876
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19601998
  4. paper describing nomenclature changes and expression in range of tissues and in response to UV PMID: 15854049
Protein Families
LCE family
Tissue Specificity
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
Database Links

HGNC: 29461

OMIM: 612613

KEGG: hsa:353142

STRING: 9606.ENSP00000335006

UniGene: Hs.553714

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