Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LUC7L3 Polyclonal antibody

Uniprot No.

O95232

Target Names

LUC7L3

Alternative Names

cAMP regulatory element-associated protein 1 antibody; Cisplatin resistance-associated overexpressed protein antibody; Cisplatin resistance-associated-overexpressed protein antibody; CRA antibody; CRE-associated protein 1 antibody; CREAP-1 antibody; CREAP1 antibody; CROP antibody; hLuc7A antibody; LC7L3_HUMAN antibody; LUC7 like 3 pre mRNA splicing factor antibody; Luc7-like protein 3 antibody; Luc7A antibody; LUC7L3 antibody; O48 antibody; OA48 18 antibody; Okadaic acid-inducible phosphoprotein OA48-18 antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens

Immunogen

Recombinant Homo sapiens LUC7L3 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Target Background

Function

Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.

Gene References into Functions

results indicate that LUC7L3, PPIG, and SFRS18 are not only implicated in EDA+ fibronectin formation, but also that they could possess multiple roles in psoriasis-associated molecular abnormalities. PMID: 28589370
LUC7 like 3 pre-mRNA splicing factor (LUC7L3, also known as hLuc7A or CROP) is a novel interacting partner of HBV enhancer II and basal core promoter. PMID: 27857158
these results show that angiotensin II and hypoxia, signals common to heart failure, result in increased LUC7L3 and RBM25 splicing regulators, increased binding of RBM25 to SCN5A mRNA, increased SCN5A splice variant abundances, decreased full-length SCN5A mRNA and protein, and decreased Na(+) current. PMID: 22939879
RBM25/LUC7L3-mediated abnormal SCN5A mRNA splicing reduced Na+ channel current 91.1+/-9.3% to a range known to cause sudden death. PMID: 21859973
These results suggest that cisplatin affects RNA splicing by changing the subnuclear distribution of proteins including cisplatin resistance-associated overexpressed protein (CROP). PMID: 12565863
Luc7A is a new U1 snRNP-associated splicing factor. PMID: 17726058

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Subcellular Location

Nucleus speckle. Note=The subnuclear localization is affected by cisplatin.

Protein Families

Luc7 family

Tissue Specificity

Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, inclu

Database Links

HGNC: 24309

OMIM: 609434

KEGG: hsa:51747

STRING: 9606.ENSP00000240304

UniGene: Hs.130293

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LUC7L3 Antibody

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