Lingo1 Antibody

Datasheet

Code	CSB-PA880476ZA01MO
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Lingo1 Polyclonal antibody

Uniprot No.

Q9D1T0

Target Names

Lingo1

Alternative Names

Lingo1 antibody; Lern1 antibody; Lrrn6a antibody; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 antibody; Leucine-rich repeat neuronal protein 1 antibody; Leucine-rich repeat neuronal protein 6A antibody

Raised in

Rabbit

Species Reactivity

Mus musculus

Immunogen

Recombinant Mus musculus Lingo1 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.

Gene References into Functions

These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1 PMID: 25681574
LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions PMID: 22514275
a novel role for LINGO-1 in neural stem cell differentiation to neurons PMID: 22235341
inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration PMID: 17726113
Lingo1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. PMID: 17906634

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.

Database Links

KEGG: mmu:235402

STRING: 10090.ENSMUSP00000059050

UniGene: Mm.246605

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Lingo1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background