Marf Antibody

1. Enhancing the profusion gene mitofusin/marf is beneficial in an in vivo model of TDP-43 proteinopathies, serving as a potential therapeutic target. PMID: 28324764
2. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria. PMID: 27336715
3. Clu is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu-deficient flies and is destabilized upon Clu overexpression. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance. PMID: 26931463
4. lack of ChChd3 leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki). Furthermore, loss of ChChd3 induces oxidative stress and activates the JNK pathway. In addition, depletion of other mitochondrial fusion components, Opa1 or Marf, inactivates the Hippo pathway as well. PMID: 27317679
5. Marf is required for mitochondrial fusion and transport in long axons. PMID: 25313867
6. Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects. PMID: 24469638
7. Parkin deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin. PMID: 24192653
8. mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology PMID: 22957060
9. Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf. PMID: 21475305
10. MARF and Opa1 control mitochondrial and cardiac function in Drosophila. PMID: 21148429
11. The PINK1/Parkin pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies. PMID: 20194754
12. Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line. PMID: 12128227

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KEGG: dme:Dmel_CG3869

STRING: 7227.FBpp0070873

UniGene: Dm.11038