mib1 Antibody

Datasheet

Code	CSB-PA896152XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) mib1 Polyclonal antibody

Uniprot No.

Q9VUX2

Target Names

mib1

Alternative Names

mib1 antibody; mind-bomb antibody; CG5841 antibody; E3 ubiquitin-protein ligase mind-bomb antibody; EC 2.3.2.27 antibody; Mind bomb homolog antibody; D-mib antibody; RING-type E3 ubiquitin transferase mind-bomb antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) mib1 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.

Gene References into Functions

While deficient Mib1 signaling leads to overgrowth of the NMJ, ubiquitous overexpression of Mib1 results in a reduction in the number of presynaptic motor neuron boutons and branches PMID: 26596173
The ubiquitylation of Delta by both Neuralized and Mindbomb1 was detected, with the two enzymes using distinct docking sites and having different acceptor lysine preferences. PMID: 22162135
Mind bomb (D-mib) associates physically and functionally with both Serrate and Delta, and is a positive component of Notch signaling that is required for multiple Neuralized-independent, Notch-dependent developmental processes. PMID: 15829515
Simultaneous absence of neuralized and mib1 completely abolishes Notch signaling in both lateral inhibition (generating single neural precursors from a field of equipotent cells)and wing dorsoventral boundary formation. PMID: 16093323

Subcellular Location

Cytoplasm, cell cortex. Note=Localizes at the apical cortex of cells.

Tissue Specificity

Ubiquitous in the wing imaginal disk (at protein level).

Database Links

KEGG: dme:Dmel_CG5841

STRING: 7227.FBpp0075275

UniGene: Dm.10758

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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mib1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background