mib1 Antibody

1. Data reported the first genome-wide analysis and transcriptome profiling of the new mib(nn2002) in Zebrafish. These results suggested that the defects in the somitogenesis were related to the down-regulated segmentation genes, such as foxc1a, smyhc1, myod1 and mylpfa. PMID: 29126925
2. Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons. PMID: 27510968
3. indicate that miR-10 regulates the angiogenic behaviour in a Notch-dependent manner by directly targeting mib1 PMID: 26825552
4. forms of DeltaD that have the MID can activate Notch in trans and suppress early neurogenesis when mRNA encoding it is ectopically expressed in zebrafish embryos. PMID: 26020642
5. Mib and Mib2 interact with Fih-1 that is involved in the hypoxia signaling pathway. PMID: 24714733
6. Data indicate a general down-regulation of Notch signaling genes necessary for proper brain development in mind bomb-mutant zebrafish embryos. PMID: 21688347
7. mind bomb mutants have downregulation of several genes necessary for GABA-mediated signaling. Spontaneous seizures are seen in these animals. PMID: 20943912
8. Mosaic analysis indicates that the bronchiomotor neurons patterning and fusion defects in the mib hindbrain arise non-cell autonomously. PMID: 14579383
9. The three functionally distinct modules of Mind bomb work cooperatively to regulate Notch signaling by associating with, ubiquitinating, and internalizing Delta. PMID: 15013799
10. Zebrafish Mib and Mib2 are colocalized in transfected cells and function redundantly in regulating Notch signaling in embryos. PMID: 17331493
11. The mib ( ta52b ) mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling pathway. PMID: 19005681
12. Mib encodes a RING ubiquitin ligase that promotes ubiquitylation and internalization of Delta. PMID: 12530964

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KEGG: dre:352910

STRING: 7955.ENSDARP00000109025

UniGene: Dr.106501