MIB1 Antibody

Code CSB-PA773868XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q804S5
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) MIB1 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias E3 ubiquitin-protein ligase mib1 (EC (Protein mind bomb) (RING-type E3 ubiquitin transferase mib1) mib1 mib
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names mib1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite, Cytoplasm, Cell membrane
Database Links

KEGG: dre:352910

STRING: 7955.ENSDARP00000109025

UniGene: Dr.106501

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