Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MORC3 Polyclonal antibody

Uniprot No.

Q14149

Target Names

MORC3

Alternative Names

KIAA0136 antibody; Microrchidia 3 antibody; MORC family CW type zinc finger 3 antibody; MORC family CW type zinc finger protein 3 antibody; MORC family CW-type zinc finger protein 3 antibody; MORC3 antibody; MORC3_HUMAN antibody; Nuclear matrix protein 2 antibody; Nuclear matrix protein NXP2 antibody; NXP2 antibody; ZCW5 antibody; ZCWCC3 antibody; Zinc finger CW type coiled coil domain 3 antibody; Zinc finger CW type coiled coil domain protein 3 antibody; Zinc finger CW type with coiled coil domain 3 antibody; Zinc finger CW-type coiled-coil domain protein 3 antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens

Immunogen

Recombinant Homo sapiens MORC3 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Target Background

Function

Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in vitro. May be required for influenza A transcription during viral infection. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.

Gene References into Functions

our studies provide a molecular framework detailing MORC3 functions and suggest that its modulation may contribute to human disease. PMID: 27653685
Dermatomyositis patients with anti-NXP-2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease. PMID: 28129490
MORC3 has antiviral activity during herpes simplex virus 1 and human cytomegalovirus infections. PMID: 27440897
Case Report: manifestations of interstitial lung disease in adult dermatomyositis patient with anti-NPX2 autoantibodies. PMID: 26028648
Downregulation of NXP2/MORC3 by use of two independent short hairpin RNAs reduced virus titers in low-multiplicity infections. Analysis of viral RNA in high-multiplicity infections showed a reduction of viral RNA and mRNA after NXP2/MORC3 downregulation. PMID: 26202233
Case Report: Pemphigus foliaceus associated with anti-NXP2 autoantibody-positive amyopathic dermatomyositis. PMID: 24217940
These studies demonstrate that anti-NXP-2 and anti-TIF-1gamma antibodies are frequent DM specificities (found in 55% of patients) and are present in most patients with cancer-associated dermatomhyositis. PMID: 24037894
An anti-MJ antibody that recognizes NXP-2 was found to be a useful biomarker in dermatomyositis-polymyositis patients. PMID: 22546500
Anti-NXP2 Ab may be associated with adult idiopathic inflammatory myopathies with malignancy. PMID: 22258483
MORC3 colocalizes with PML by a two-step molecular mechanism. PMID: 20501696
determination of nuclear matrix-binding, RNA-binding, and coiled-coil domans PMID: 11927593
When tethered to a promoter by fusion to Gal4, NXP-2 repressed transcription, consistent with a role for NXP-2 in SUMO-mediated repression PMID: 16567619
MORC3 (microrchidia3)-ATPase activated p53 and induced cellular senescence in normal fibroblasts but not p53-/- fibroblasts PMID: 17332504

Hide All

Subcellular Location

Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body.

Tissue Specificity

Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.

Database Links

HGNC: 23572

OMIM: 610078

KEGG: hsa:23515

STRING: 9606.ENSP00000383333

UniGene: Hs.421150

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MORC3 Antibody

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