NRG1 Antibody

Code CSB-PA966535XA01CZD
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) NRG1 Polyclonal antibody
Uniprot No.
Target Names
NRG1
Alternative Names
NRG1 antibody; CAALFM_C704230WA antibody; CaO19.7150 antibody; Transcriptional regulator NRG1 antibody
Raised in
Rabbit
Species Reactivity
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Immunogen
Recombinant Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) NRG1 protein
Immunogen Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament-specific gene expression in response to inducing conditions. Plays a key role in biofilm formation and dispersion. Plays also the role of a negative regulator of virulence in mice models. Required for the expression of the cell wall genes RBR1.
Gene References into Functions
  1. Candida albicans can express iron assimilation genes independently of NRG1 levels. PMID: 22888912
  2. Nrg1p as a key regulator of the C. albicans biofilm life cycle. PMID: 20709787
  3. The increased rate of hypha formation in C. albicans relative to C. dubliniensis in response to phagocytosis by macrophages and serum was associated with rapid downregulation of NRG1 expression in C. albicans. PMID: 17927699
Subcellular Location
Nucleus.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1