Nrl Antibody

1. that two photoreceptor-specific transcription factors, NRL and CRX, are master regulators of this program and are required for tumor maintenance in this subgroup PMID: 29533784
2. Following Nrl disruption, rods gain partial features of cones and present with improved survival in the presence of mutations in rod-specific genes, consequently preventing secondary cone degeneration. In three different mouse models of retinal degeneration, the treatment substantially improves rod survival and preserves cone function. PMID: 28291770
3. Nrl is posttranscriptionally regulated to facilitate the generation of other cell types in retina PMID: 27878762
4. De novo assembly and alternative splicing analyses revealed previously unannotated rod-enriched transcripts and the role of NRL in transcript maturation. PMID: 27880916
5. Our studies reveal coregulation of coding and noncoding transcripts in rod photoreceptors by NRL and establish the framework for deciphering the function of ncRNAs during retinal development. PMID: 28863214
6. To explore dendritic stratification of OFF bipolar cells in the absence of rods, we made use of the 'cone-full' Nrl-/- mouse retina in which all photoreceptor precursor cells commit to a cone fate including those which would have become rods in wild-type retinas PMID: 28257490
7. CNGA3 expression restored cone function in in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia. PMID: 25855802
8. REEP6.1 is a key functional target of NRL-centered transcriptional regulatory network in rod photoreceptors. PMID: 24691551
9. Data indicate that positive feedback between neural retina leucine zipper factor (NRL) and retinoid-related orphan receptor beta gene (Rorb) genes reinforces the commitment to a rod differentiation fate. PMID: 25296752
10. shRNA-mediated knockdown of Crx and Nrl resulted in reduced Kcnv2 promoter activity and low endogenous Kcnv2 mRNA expression in the retina. PMID: 24664678
11. This study analyzed the retinal pigment epithelium from Nrl(-/-) mice of various ages for lipofuscin fluorescence and A2E levels. PMID: 22417141
12. Findings suggest that elimination of Nrl in adult rods may represent a unique therapy for retinal degeneration. PMID: 23319618
13. Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module PMID: 22511886
14. found that Nrl activated rhodopsin and Ppp2r5c transcription by recruiting Tip60 to promote histone H3/H4 acetylation PMID: 22354990
15. Nrl as a direct transcriptional target of RORbeta and suggest that combinatorial action of multiple regulatory factors modulates the expression of Nrl in developing and mature retina. PMID: 21673114
16. Nrl-deficient retina may serve as a model for elucidating mechanisms of cone homeostasis and degeneration that would be relevant to understanding diseases of the cone-dominant human macula. PMID: 22238088
17. a model in which Nrl expression is primarily initiated by OTX2 and RORbeta and later maintained at high levels by CRX and RORbeta. PMID: 21865162
18. Cone-like outer segment phagocytosis in Nrl(-/-) mice shows a similar profile to that of rods in normal mice and other species. PMID: 21203345
19. results suggest that Ppp2r5c expression is regulated by Nrl during retinogenesis through direct binding to the promoter region of Ppp2r5c PMID: 21078119
20. Studies suggest an important role of sumoylation in fine-tuning the activity of NRL and thereby incorporating yet another layer of control in gene regulatory networks involved in photoreceptor development and homeostasis. PMID: 20551322
21. the function of NRL is modulated by its interaction with specific repressor proteins, related to cross-talk between signaling pathways in the retina PMID: 12566383
22. both Nrl and Crx are required for full transcriptional activity of the PDE6A gene PMID: 15001570
23. a 2.5-kb Nrl promoter segment directs the expression of enhanced GFP specifically to rod photoreceptors and the pineal gland PMID: 16505381
24. NRL is not only essential but is sufficient for rod differentiation PMID: 17242361
25. Nrl and Grk1 have roles in photoresponse recovery and age-related degeneration PMID: 17249566
26. Rorbeta directs rod development and does so in part by inducing the Nrl-mediated pathway of rod differentiation. PMID: 19805139

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KEGG: mmu:18185

STRING: 10090.ENSMUSP00000054457

UniGene: Mm.20422