OMA1 Antibody

Code CSB-PA339648XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) OMA1 Polyclonal antibody
Uniprot No. P36163
Target Names OMA1
Alternative Names OMA1; YKR087C; YKR407; Mitochondrial metalloendopeptidase OMA1
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) OMA1 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Protease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OXA1 and COX1. Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Cleaves the misfolded multi-pass membrane protein OXA1. Involved in quality control of cytochrome oxidase assembly: mediates the cleavage of COX1 in cells lacking COA2. Required for the stability of the respiratory supercomplexes. Required for TOR signaling.
Gene References into Functions
  1. Study shows that in Saccharomyces cerevisiae, inactivation of the membrane-bound intramitochondrial quality control protease Oma1 interferes with oxidative-stress responses through enhanced production of reactive oxygen species during logarithmic growth and reduced stress signaling via the TORC1-Rim15-Msn2/Msn4 axis. PMID: 27325672
  2. yeast Oma1 is an important player in IM protein homeostasis and integrity by acting in concert with other intramitochondrial quality control components. PMID: 24648523
  3. Specific Cox1 proteolysis in coa2Delta cells arises from a combination of Oma1 activation and a susceptible conformation of Cox1. PMID: 22219186
Subcellular Location Mitochondrion inner membrane; Single-pass membrane protein.
Protein Families Peptidase M48 family
Database Links

KEGG: sce:YKR087C

STRING: 4932.YKR087C

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