Pard3 Antibody

Code CSB-PA017444XA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Pard3 Polyclonal antibody
Uniprot No.
Target Names
Pard3
Alternative Names
Pard3 antibody; Par3 antibody; Partitioning defective 3 homolog antibody; PAR-3 antibody; PARD-3 antibody; Atypical PKC isotype-specific-interacting protein antibody; ASIP antibody; Atypical PKC-specific-binding protein antibody; ASBP antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus (Rat)
Immunogen
Recombinant Rattus norvegicus (Rat) Pard3 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. Involved in Schwann cell peripheral myelination. Targets the phosphatase PTEN to cell junctions.
Gene References into Functions
  1. transcriptional upregulation of Girdin expression and Girdin-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex. PMID: 25977476
  2. PAR3 interacts with PAR6 and NGL-2, acting together to regulate axon differentiation. PMID: 25948265
  3. results suggest that ERK2 phosphorylates Par3 and inhibits its binding with KIF3A, thereby controlling Par3 transport and neuronal polarity PMID: 23946386
  4. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. PMID: 22128191
  5. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology. PMID: 21685893
  6. These data suggest that the putative phospholipid binding by par-3 is important for its localization at cell-cell junctions. PMID: 21467691
  7. up-regulation of miR-491-5p contributes to TGF-beta-regulated Par-3 expression. PMID: 20966078
  8. Data show that Aurora A interacts directly with the atypical protein kinase C binding domain of Par3 and phosphorylates it at serine 962. PMID: 19812038
  9. the CR1-mediated self-association of the PAR-3-containing protein complex plays a role during the formation of functional tight junctions. PMID: 12756256
  10. PAR-3 regulates spine formation by binding the Rac guanine nucleotide-exchange factor (GEF) TIAM1, and spatially restricting it to dendritic spines. PMID: 16474385
  11. Par-3 localizes asymmetrically in Schwann cells at the axon-glial junction; disruption of Par-3 localization inhibits myelination; Par-3 associates & recruits p75 neurotrophin receptor to the axon-glial junction forming a complex needed for myelination PMID: 17082460
  12. The Par-3 N-terminal oligomerization domain adopts a PB1-like structure required for Par-3 oligomerization and membrane localization. PMID: 17476308
  13. downregulation of Par-3 and subsequent disruption of Par complex integrity might be one mechanism that TGF-beta destroys cell polarity during epithelial to mesenchymal transition PMID: 18070611
  14. Par-3 functions as a scaffold in integrating phosphoinositide signaling events during cellular polarization PMID: 18550519
  15. the Par6/Par3-based polarity complex likely coordinates the events of apical ectoplasmic specialization and blood-testis barrier restructuring that take place concurrently at the opposing ends of adjacent Sertoli cells during spermatogenesis PMID: 18621709
  16. Results identify a new role for local translation and the PAR complex in axonal outgrowth. PMID: 19620967

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Subcellular Location
Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell junction, adherens junction. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane.
Protein Families
PAR3 family
Tissue Specificity
Isoform 1 is predominantly expressed in lung, glandular stomach, prostate, ovary and uterus. Isoform 1 is also expressed in brain, with a high expression in the cortex, hippocampus and in the striatum. Isoform 2 is predominantly expressed in intestinal ep
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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