PDLIM3 Antibody

Code CSB-PA690477ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDLIM3 Polyclonal antibody
Uniprot No.
Target Names
PDLIM3
Alternative Names
Actinin associated LIM protein antibody; Actinin-associated LIM protein antibody; Alpha actinin 2 associated LIM protein antibody; Alpha-actinin-2-associated LIM protein antibody; DKFZp686L0362 antibody; Enigma homolog antibody; PDLI3_HUMAN antibody; PDLIM 3 antibody; PDLIM3 antibody; PDZ and LIM domain 3 antibody; PDZ and LIM domain protein 3 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens PDLIM3 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
May play a role in the organization of actin filament arrays within muscle cells.
Gene References into Functions
  1. This study confirmed that PDLIM3 as genetic modifiers of age at onset of Alzheimer disease. PMID: 26214276
  2. two abnormal splicing events for actinin-associated LIM protein 3 (PDLIM3/ALP) and fibronectin 1 (FN1) in the skeletal muscles of myotonic dystrophy type 1 patients. PMID: 21549096
  3. mutations in PDLIM3 and MYPN are infrequent in hypertrophic cardiomyopathies PMID: 20801532
  4. ZASP-like motif in actinin-associated LIM protein is required for interaction with the alpha-actinin rod and for targeting to the muscle Z-line PMID: 15084604
  5. Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM. PMID: 17254821

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Subcellular Location
Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
Tissue Specificity
Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
Database Links

HGNC: 20767

OMIM: 605889

KEGG: hsa:27295

STRING: 9606.ENSP00000284770

UniGene: Hs.701364

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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