PLCD3 Antibody

Code CSB-PA822696XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLCD3 Polyclonal antibody
Uniprot No.
Target Names
PLCD3
Alternative Names
PLCD3 antibody; KIAA1964 antibody; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 antibody; EC 3.1.4.11 antibody; Phosphoinositide phospholipase C-delta-3 antibody; Phospholipase C-delta-3 antibody; PLC-delta-3 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) PLCD3 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling.
Gene References into Functions
  1. Results identified an interaction between PLCD3 and FLOT2. Inhibition of PLCD3 expression impaired the malignant potential of nasopharyngeal carcinoma (NPC) cells, by restraining its growth, proliferation, mobility and migration. This study demonstrated that PLCD3 may be an oncogenic protein in NPC and that it plays an important role in the progression of NPC partially by interacting with Flot2. PMID: 29115528
  2. PLCdelta3 regulates microvilli formation in enterocytes and the radial migration of neurons in the cerebral cortex of the developing brain. [review] PMID: 23948486
  3. In mouse, Plcd1 and Plcd3 may act together in murine hair follicles. PMID: 22723964
  4. Data are consistent with the idea that phospholipase C d1 and d3 isoforms support the growth and migration of normal and neoplastic mammary epithelial cells in vitro. PMID: 19344632
Subcellular Location
Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow.
Tissue Specificity
Present in corneal epithelial cells (at protein level).
Database Links

HGNC: 9061

OMIM: 608795

KEGG: hsa:113026

STRING: 9606.ENSP00000313731

UniGene: Hs.380094

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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