Myt1 Antibody

Code CSB-PA889054XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Myt1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Myt1 antibody; CG32417 antibody; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase antibody; EC 2.7.11.1 antibody; Myt1 kinase antibody; dMyt1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Myt1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins. Mediates phosphorylation of Cdk1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of Cdk1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Gene References into Functions
  1. Myt1 serves unique Cdk1 regulatory functions required for efficient coupling of cell differentiation with cell cycle progression. PMID: 16107480
  2. dMyt1 serves Cdk1 regulatory functions that are important both for normal cell-cycle progression and for coordinating mitosis with critical developmental processes PMID: 18940789
Subcellular Location
Golgi apparatus membrane; Peripheral membrane protein.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
Database Links

KEGG: dme:Dmel_CG32417

STRING: 7227.FBpp0076824

UniGene: Dm.4639

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