Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PRELID1 Polyclonal antibody

Uniprot No.

Q9Y255

Target Names

PRELID1

Alternative Names

25 kDa protein of relevant evolutionary and lymphoid interest antibody; CGI 106 antibody; MGC87972 antibody; mitochondrial antibody; PRELI antibody; PRELI domain containing 1 antibody; PRELI domain containing protein 1 antibody; PRELI domain containing protein 1 mitochondrial antibody; PRELI domain-containing protein 1 antibody; PRELID 1 antibody; PRELID1 antibody; PRLD1_HUMAN antibody; Protein of relevant evolutionary and lymphoid interest antibody; PX 19 antibody; PX19 antibody; Px19 like protein antibody; Px19, chicken, homolog of antibody; Px19-like protein antibody; SBBI12 antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) PRELID1 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.

Gene References into Functions

This study suggests that the regulation of PRELID1 expression, by alternative polyadenylation and other mechanisms, plays a role in mitochondrial ROS signaling and represents a novel prognostic factor and therapeutic target in cancer PMID: 28912168
PRELI plays an important role in the suppression of apoptosis in HepG2 cells in response to oxidative stress. PMID: 26275693
Loss of TRIAP1 or PRELI impairs the accumulation of Cardiolipin, facilitates the release of cytochrome c, and renders cells vulnerable to apoptosis upon intrinsic and extrinsic stimulation. PMID: 23931759
PRELI is a vital LEA B cell protein with failsafe genetics PMID: 22666421
PRELI interacts with OPA1 to maintain mitochondria structures intact, sustain balanced ion(-)/proton(+) gradients, promote oxidative phosphorylation reactions, regulate pro- and antiapoptotic protein traffic and enable cell responses to induced death. PMID: 21364629

Hide All

Subcellular Location

Mitochondrion. Mitochondrion intermembrane space.

Tissue Specificity

Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes.

Database Links

HGNC: 30255

OMIM: 605733

KEGG: hsa:27166

STRING: 9606.ENSP00000302114

UniGene: Hs.744904

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：
Please enter the characters shown. Click the image to refresh if unclear.

Code	CSB-PA896867XA01HU
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

PRELID1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background