Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Rbfox3 Polyclonal antibody

Uniprot No.

Q8BIF2

Target Names

Rbfox3

Alternative Names

Rbfox3 antibody; D11Bwg0517e antibody; Hrnbp3 antibody; RNA binding protein fox-1 homolog 3 antibody; Fox-1 homolog C antibody; Hexaribonucleotide-binding protein 3 antibody; Fox-3 antibody; Neuronal nuclei antigen antibody; NeuN antigen antibody

Raised in

Rabbit

Species Reactivity

Mus musculus

Immunogen

Recombinant Mus musculus Rbfox3 protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

Target Background

Function

Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).

Gene References into Functions

Rbfox3-/- mice displayed normal non-image and image forming functions. Taken together, our results suggest RBFOX3 is dispensable for visual function PMID: 29401485
Results demonstrate the important role of RBFOX3 during neural development and maturation and show that abnormalities in synaptic structure and function occur in Rbfox3 homozygous knockout mice. These findings may offer mechanistic explanations for human brain diseases associated with dysfunctional RBFOX3. PMID: 27701470
RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function. PMID: 26619789
In vitro analyses revealed that Rbfox3 functions as a positive and a negative regulator at the stage of pri-miRNA processing to precursor miRNA (pre-miRNA). PMID: 25240799
Rbfox3-dependent Numb alternative splicing plays an important role in the progression of neuronal differentiation during vertebrate development. PMID: 23420872
the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism PMID: 21747913
During the development of olfactory bulb and epithelium, NeuN is expressed only in mature neural cells migrating from margin area to the inner granule cells layer of olfactory bulb. PMID: 17608158
NeuN is the Fox-3 gene product and its expression is restricted to neural tissues. PMID: 19713214
Enzymatic dephosphorylation abolishes NeuN immunoreactivity, confirming that NeuN is indeed a phosphoprotein, and establishing that binding of the defining antibody depends on its state of phosphorylation. PMID: 15605376

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Subcellular Location

Nucleus. Cytoplasm.; [Isoform 1]: Nucleus.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Nucleus.

Tissue Specificity

Widely expressed in brain, including in cerebral cortex, hippocampus, thalamus, caudate/putamen, cerebellum, as well as in the spinal cord (at protein level). Not expressed in all neuronal cells within a region, in cerebellum, expression is absent in Purk

Database Links

KEGG: mmu:52897

STRING: 10090.ENSMUSP00000017576

UniGene: Mm.341103

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Rbfox3 Antibody

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Target Background