Bin1 Antibody

Code CSB-PA895601XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Bin1 Polyclonal antibody
Uniprot No.
Target Names
Bin1
Alternative Names
Bin1 antibody; SAP18 antibody; CG6046 antibody; Histone deacetylase complex subunit SAP18 antibody; 18 kDa Sin3-associated polypeptide antibody; Bicoid-interacting protein 1 antibody; dSAP18 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Bin1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in the tethering of the SIN3 complex to core histone proteins. Interacts with bicoid (bcd) to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction. Interacts with Trl and binds to Polycomb response elements at the bithorax complex. May contribute to the regulation of other homeotic gene expressions.
Gene References into Functions
  1. The findings reveal the ability of Bin1 to modify actin dynamics and provide a possible mechanistic connection between Bin1 and tau-induced pathobiological changes of the actin cytoskeleton. PMID: 28893863
  2. dSAP18 is a key player in transcriptional responses to stress. PMID: 21146528
  3. removal of maternal sap18 results in embryos that are missing labrally derived parts of the cephalopharyngeal skeleton PMID: 15649476
  4. Drosophila dSAP18 protein is a nuclear protein that associates with chromosomes and the nuclear matrix and interacts with pinin involved in RNA splicing. PMID: 16823614
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
SAP18 family
Database Links

KEGG: dme:Dmel_CG6046

STRING: 7227.FBpp0082731

UniGene: Dm.20197

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