SEN1 Antibody

1. The helicase domain (HD) is sufficient to dissociate the elongation complex (EC) in vitro. Both full-length Sen1 and its HD can translocate along single-stranded RNA and DNA in the 5 to 3 direction. PMID: 28180347
2. we identify new targets and functions of Sen1-dependent termination, including a role in repression of meiotic genes in vegetative cells. In combination with other recent whole-genome studies on termination of non-coding RNAs, our results provide promising directions for further investigation. PMID: 28665995
3. The authors also show that subdomain 1C (the "prong") is an essential element for 5'-3' unwinding of RNA and for Sen1-mediated transcription termination in vitro. PMID: 28408439
4. DNA/RNA helicase Sen1 mutant causes modulation of protein-serine-threonine kinase TOR pathway and autophagy. PMID: 27718307
5. Data indicate that mutant of the RNA processing machinery (RNT1), and RNA/DNA helicase SEN1 mutants that are unable to interact with Rnt1p, exhibit a flocculation phenotype. PMID: 26364722
6. results are consistent with a model in which Sen1 promotes transcription termination by resolving R-loops. PMID: 26198638
7. We provide evidence that this topological stress contributes to recruit and/or stabilize condensin at Pol III-transcribed genes in the absence of Swd2.2 and Sen1 PMID: 25392932
8. Multiple domains of Sen1 are involved in transcription termination. PMID: 25116135
9. Sen1p recognizes the nascent RNA & hydrolyzes ATP to dissociate the elongation complex. Sen1p-dependent transcription termination is highly specific & does not require the C-terminal domain of RNAPII. PMID: 23748379
10. Study shows that the Sen1/Senataxin DNA/RNA helicase associates with forks, promoting their progression across RNA polymerase II (RNAPII)-transcribed genes. PMID: 23141540
11. Analysis of a homogeneous set of several hundreds of artificial, Nrd1-Nab3-Sen1 complex-dependent terminators revealed novel and extended sequence determinants for transcription termination, as well as supermotifs critical for termination. PMID: 23032188
12. transcriptome-wide distribution of termination factors Nrd1, Nab3, and Sen1 is reported. PMID: 22028667
13. show here that Nrd1, Nab3, and Sen1 bind to a number of noncoding RNAs in an unexpected manner PMID: 21954178
14. Data suggest that Set1 promotes proper early termination by the Nrd1-Nab3-Sen1 complex by affecting the kinetics of Pol II transcription in early elongation. PMID: 21709022
15. Findings reveal a regulatory mechanism in which Mpk1 overcomes transcriptional attenuation by blocking recruitment of the Sen1-Nrd1-Nab3 termination complex to the elongating polymerase. PMID: 21376235
16. Sen1p-Rpb1p and Sen1p-Rnt1p interactions occur independently of each other and serve genetically separable purposes in targeting Sen1p to function in two temporally overlapping steps in gene expression. PMID: 19884310
17. the Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain PMID: 18660819

Show More

Hide All

KEGG: sce:YLR430W

STRING: 4932.YLR430W