SOX2 Antibody

Code CSB-PA761266XA01DIL
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Product Details

Full Product Name Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) sox2 Polyclonal antibody
Uniprot No. Q6P0E1
Target Names sox2
Alternative Names sox2 antibody; zgc:65860 antibody; zgc:77389 antibody; Transcription factor Sox-2 antibody
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) SOX2 protein
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

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Target Data

Function Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Gene References into Functions
  1. Findings indicate a pivotal role for ZNF32 function in SOX2 expression and regeneration regulation. PMID: 27626680
  2. Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration. PMID: 26609166
  3. a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury PMID: 25150399
  4. Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. PMID: 24498133
  5. By western blot three protein bands of 28 kDa, 34 kDa (main band), and 38 kDa were detected in the brain of animals 180 days post-fertilizaton. PMID: 20734413
  6. significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos. PMID: 21820425
  7. sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration PMID: 20025865
  8. shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs PMID: 19800392
  9. zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line PMID: 17443814
  10. Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters. PMID: 19767420

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Subcellular Location Nucleus, Cytoplasm
Tissue Specificity At the shield stage, expressed uniformly in the future ectoderm. At the 75-80% epiboly stage, becomes localized to the presumptive neuroectoderm; strong expression in the presumptive forebrain, weak expression in the presumptive spinal cord. At the tail b
Database Links

KEGG: dre:378723

STRING: 7955.ENSDARP00000095266

UniGene: Dr.5379

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