SRP72 Antibody

Code CSB-PA022677ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SRP72 Polyclonal antibody
Uniprot No.
Target Names
SRP72
Alternative Names
Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein), SRP72
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens SRP72 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
Gene References into Functions
  1. SRP72 depletion is associated with elevated levels of apoptosis after irradiation. PMID: 28494188
  2. A heterozygous mutation in SRP72 has a role in familial aplasia and myelodysplasia. PMID: 22541560
  3. The study delineated the minimal region of SRP72 capable of forming a stable complex with an signal recognition particle RNA fragment. PMID: 21073748
  4. Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells. PMID: 20729213
  5. Human SRP RNA bound with high affinity to a 63 amino acid residue region near the C terminus of SRP72 PMID: 15588816
  6. Ninety-four amino acids near the C terminus of SRP68 mediated the binding to SRP72 PMID: 16672232
  7. Human signal recognition particle RNA with a single A240G change was unable to form a complex with full-length human SRP72. PMID: 18441046

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Involvement in disease
Bone marrow failure syndrome 1 (BMFS1)
Subcellular Location
Cytoplasm. Endoplasmic reticulum.
Protein Families
SRP72 family
Database Links

HGNC: 11303

OMIM: 602122

KEGG: hsa:6731

STRING: 9606.ENSP00000342181

UniGene: Hs.237825

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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