Sostdc1 Antibody

Code CSB-PA866588ZA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Sostdc1 Polyclonal antibody
Uniprot No.
Target Names
Sostdc1
Alternative Names
Sostdc1 antibody; Sostl antibody; Usag1 antibody; Sclerostin domain-containing protein 1 antibody; Ectodermal BMP inhibitor antibody; Ectodin antibody; Sclerostin-like protein antibody; Uterine sensitization-associated gene 1 protein antibody; USAG-1 antibody
Raised in
Rabbit
Species Reactivity
Mus musculus
Immunogen
Recombinant Mus musculus Sostdc1 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
Gene References into Functions
  1. Sostdc1 may promote and maintain mesenchymal stem cell quiescence in the periosteum. PMID: 27102547
  2. suggest that RUNX2 and USAG-1 act in an antagonistic manner PMID: 27518316
  3. the in vivo inter-relationships between Bmp7 and Usag-1, was examined. PMID: 27178071
  4. Findings strongly suggest that Wise and Sost are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 and control the balance or levels of Wnt signaling. PMID: 24789067
  5. Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations PMID: 24816837
  6. Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. PMID: 23994639
  7. Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt/beta-catenin signaling. PMID: 23293290
  8. Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor) and gremlin in islets after high-fat diet. PMID: 22829579
  9. The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 and USAG-1. PMID: 22525429
  10. The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt/beta-catenin signaling. PMID: 22509524
  11. analyses demonstrate that the Fgf and Shh pathways are major downstream targets of Wise-regulated Wnt signaling. PMID: 20724449
  12. the pathogenetic role of USAG-1 in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 may be a promising therapeutic approach for the treatment of Alport syndrome. PMID: 20197625
  13. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
  14. reported that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of enamel knots; proposed that ectodin is critical for robust spatial delineation of enamel knots and cusps PMID: 16179481
  15. Uterine sensitization-associated gene-1 (USAG-1) plays a critical role in the modulation of renoprotective action of bone morphogenetic protein. PMID: 16341262
  16. Expression of USAG-1 mRNA appears to be associated with blastocyst implantation to the luminal epithelium, suggesting that physiological or biochemical contact of the blastocyst to the uterus is required for USAG-1 expression PMID: 17389776
  17. USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis PMID: 17555714
  18. Enhanced BMP signaling results in supernumerary teeth and BMP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model. PMID: 18329379
  19. minimizing the amount of dental mesenchyme in cultured Sostdc1-deficient incisors causes the formation of additional de novo incisors that resemble the successional incisor development that results from activated Wnt signaling. PMID: 19141669

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Subcellular Location
Secreted.
Protein Families
Sclerostin family
Tissue Specificity
Highly expressed in kidney at renal collecting ducts level and weakly in brain.
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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