Recombinant Mouse Sclerostin domain-containing protein 1 (Sostdc1)

In Stock Promotion
Code CSB-EP866588MO
MSDS
Size $388
Order now
Promotion
Promotional price as low as $99
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
Greater than 85% as determined by SDS-PAGE.
Target Names
Sostdc1
Uniprot No.
Research Area
Signal Transduction
Alternative Names
Sostdc1; Sostl; Usag1; Sclerostin domain-containing protein 1; Ectodermal BMP inhibitor; Ectodin; Sclerostin-like protein; Uterine sensitization-associated gene 1 protein; USAG-1
Species
Mus musculus (Mouse)
Source
E.coli
Expression Region
24-206aa
Target Protein Sequence
FKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSSTGLDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESVSPAKPAQHHRERKRASKSSKHSLS
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
27.6 kDa
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 10xHis-tagged and C-terminal Myc-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description

The Recombinant Mouse Sostdc1 represents a breakthrough in the scientific study of signal transduction. Comprising a complete replica of the mature Sclerostin domain-containing protein 1, our product is designed for exactness in the research of the complex biological pathways involving this protein, also known as Ectodermal BMP inhibitor, Sclerostin-like protein, or Uterine sensitization-associated gene 1 protein (USAG-1).

The Recombinant Mouse Sostdc1 is carefully expressed from an E.coli system, with the protein length extending from amino acid 24 to 206. Its structure includes an N-terminal 10xHis-tag and a C-terminal Myc-tag for easy detection and purification. The purity of the product is established to be more than 85% as determined by SDS-PAGE, ensuring you receive a product of high quality and consistency. Depending on your requirements, it can be availed in two forms - liquid or lyophilized powder.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
Gene References into Functions
  1. Sostdc1 may promote and maintain mesenchymal stem cell quiescence in the periosteum. PMID: 27102547
  2. suggest that RUNX2 and USAG-1 act in an antagonistic manner PMID: 27518316
  3. the in vivo inter-relationships between Bmp7 and Usag-1, was examined. PMID: 27178071
  4. Findings strongly suggest that Wise and Sost are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 and control the balance or levels of Wnt signaling. PMID: 24789067
  5. Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations PMID: 24816837
  6. Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. PMID: 23994639
  7. Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt/beta-catenin signaling. PMID: 23293290
  8. Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor) and gremlin in islets after high-fat diet. PMID: 22829579
  9. The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 and USAG-1. PMID: 22525429
  10. The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt/beta-catenin signaling. PMID: 22509524
  11. analyses demonstrate that the Fgf and Shh pathways are major downstream targets of Wise-regulated Wnt signaling. PMID: 20724449
  12. the pathogenetic role of USAG-1 in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 may be a promising therapeutic approach for the treatment of Alport syndrome. PMID: 20197625
  13. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
  14. reported that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of enamel knots; proposed that ectodin is critical for robust spatial delineation of enamel knots and cusps PMID: 16179481
  15. Uterine sensitization-associated gene-1 (USAG-1) plays a critical role in the modulation of renoprotective action of bone morphogenetic protein. PMID: 16341262
  16. Expression of USAG-1 mRNA appears to be associated with blastocyst implantation to the luminal epithelium, suggesting that physiological or biochemical contact of the blastocyst to the uterus is required for USAG-1 expression PMID: 17389776
  17. USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis PMID: 17555714
  18. Enhanced BMP signaling results in supernumerary teeth and BMP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model. PMID: 18329379
  19. minimizing the amount of dental mesenchyme in cultured Sostdc1-deficient incisors causes the formation of additional de novo incisors that resemble the successional incisor development that results from activated Wnt signaling. PMID: 19141669

Show More

Hide All

Subcellular Location
Secreted.
Protein Families
Sclerostin family
Tissue Specificity
Highly expressed in kidney at renal collecting ducts level and weakly in brain.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*