Tnfsf18 Antibody

1. the upregulation of IFN-beta in DCs induces the up-regulation of coinhibitory molecules B7H1 and GITRL, which cause an impaired activation of naive Ag-specific T cells PMID: 25144375
2. GITRL expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR-dependent actions. The GITRL-GITR pathway might represent a novel target for the treatment of neuropathic pain. PMID: 25787078
3. Down-regulation of GITRL enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus. PMID: 25281716
4. Sjogren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand. PMID: 23301790
5. GITRL triggering in endothelial cells increases leukocyte adhesion and transmigration. PMID: 23892569
6. The B7H1 and GITRL molecules may play an important role in TGF-beta-induced Treg expansion of lung cancer microenvironment. PMID: 22614805
7. results demonstrate that enhanced GITR/GITRL interactions have a pleiotropic role on the regulation of T-cell responses PMID: 22678896
8. B cell expression of GITRL induced Treg proliferation, maintaining their numbers above a threshold required for the prevention of autoimmunity. PMID: 22368274
9. Findings suggest GITRL could enhance the immune stimulation of DC and might facilitate the potential development of DCs-based anti-tumor therapies. PMID: 21186078
10. GITRL-dependent expansion of Treg within the cornea is one mechanism underlying immune privilege in corneal allografts. PMID: 20702832
11. GITR and GITRL are functionally expressed on brain microglia and that the stimulation of GITRL can induce inflammatory activation of microglia. The GITR/GITRL system may play an important role in neuroinflammation. PMID: 20162721
12. TRAIL- and GITRL-activated pathways synergise in the development of SCI-related inflammatory damage. PMID: 20107429
13. GITROL ligation of the costimulatory molecule GITR on Tregs inhibits their ability to promote graft survival. Blocking GITRL with a soluble GITR fusion protein prolongs graft survival. PMID: 20148423
14. the GITR/GITRLigand pathway has a key role in the development of murine autoimmune diabetes PMID: 19936238
15. glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells PMID: 14608036
16. A soluble form of mouse GITR ligand (sGITR-L) induces GITR-dependent NF-kappa B activation and blocks in vitro suppression mediated by both resting and preactivated polyclonal and antigen-specific regulatory T (Treg) cells. PMID: 15128759
17. GITR-L provides an important signal for CD25- T cells, rendering them resistant to CD25+ -mediated regulation at the initiation of the immune response. PMID: 15470044
18. specific oligomeric forms of GITRL may be used as a means to differentially control GITR receptor signaling in diverse cells PMID: 18178614
19. the unique structural and biochemical behavior of mouse GITRL, along with the unusual domain organization of murine GITR, support a previously unrecognized mechanism for signaling within the TNF superfamily PMID: 18182486
20. GITRL-costimulation augments both effector and regulatory functions of CD4(+) T cells. PMID: 18346459
21. signaling between GITR-L and GITR in the tumor microenvironment promotes the infiltration of CD8+ T cells, which are essential for controlling tumor growth. PMID: 19018533
22. The GITR-GITR ligand pathway, mediated by interactions with epidermal keratinocytes and Langerhans cells, promotes cutaneous dendritic cell migration and hapten-specific T cell responses. PMID: 19234165
23. during fungal infection, GITRL-GITR interaction modulates TLR-4 and TLR-2 expression, thereby altering the antigen presentation process, and suggesting a role of GITRL-GITR interaction in resistance against infectious diseases. PMID: 19272591
24. The S2 cell-expressed murine GITRL adopts an identical ;strand-exchanged' dimeric structure to that observed for the E. coli-expressed protein, thus conclusively demonstrating the novel quaternary structure assembly behavior of murine GITRL. PMID: 19390148
25. keratinocytes express GITRL, and that through this important co-stimulatory molecule, they have the potential to influence T-cell numbers in the skin through chemokine production and through a direct cell-cell effect on T-cell proliferation PMID: 19536139
26. GITRL requires trimer stabilization for activation PMID: 19596991

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KEGG: mmu:240873

STRING: 10090.ENSMUSP00000083251

UniGene: Mm.276823