Tnfsf18

TNFSF18 (Tumor Necrosis Factor Superfamily Member 18), also known as GITRL (Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand), is a protein within the Tumor Necrosis Factor superfamily. It interacts with its receptor GITR, and this interaction can activate T cells and other immune cells, promoting immune responses. The structure of TNFSF18 includes an extracellular domain for binding to GITR, a transmembrane domain, and an intracellular domain for activating signaling pathways. The TNFSF18/GITR signaling pathway plays a crucial role in regulating the activity and function of T cells, particularly in anti-tumor immunity. Research on TNFSF18 has generated widespread interest in fields such as cancer therapy, autoimmune disease treatment, and transplant immunology. Understanding the regulation of the TNFSF18/GITR signaling pathway can aid in the development of novel immunotherapeutic strategies.

Popular Product

Recombinant Human Tumor necrosis factor ligand superfamily member 18(TNFSF18),partial (Active) CSB-MP891791HU

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized TNFRSF18 at 2 μg/ml can bind TNFSF18 (CSB-MP891791HU), the EC₅₀ is 2.565 to 2.940 ng/ml.

LSPR

Activity: Human TNFRSF18 protein hFc tag (CSB-MP896537HU) captured on COOH chip can bind Human TNFSF18 protein hFc and Flag tag (CSB-MP891791HU) with an affinity constant of 38.5 nM as detected by LSPR Assay.