Toll-6 Antibody

Code CSB-PA152744XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Toll-6 Polyclonal antibody
Uniprot No.
Target Names
Toll-6
Alternative Names
Toll-6 antibody; Tl-6 antibody; CG7250 antibody; Toll-like receptor 6 antibody; EC 3.2.2.6 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Toll-6 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Toll-related receptor which binds to the neurotrophin spz5. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation. Promotes heterophilic cell adhesion with 18w in vitro. May be an upstream component of the NF-kappa-B (rel) regulatory cascade.
Gene References into Functions
  1. This study demonistrated that Toll-6 have neurotrophic functions in the Drosophila CNS matching those of DNT1 and DNT2 also pleiotropic functions, maintaining predominantly interneuron survival and regulating motor-axon targeting. PMID: 23892553
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Toll-like receptor family
Database Links

KEGG: dme:Dmel_CG7250

STRING: 7227.FBpp0297411

UniGene: Dm.2661

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