Toll-7 Antibody

Code CSB-PA219267XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Toll-7 Polyclonal antibody
Uniprot No.
Target Names
Toll-7
Alternative Names
Toll-7 antibody; CG8595Toll-like receptor 7 antibody; EC 3.2.2.6 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Toll-7 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Toll-related receptor which binds to the neurotrophins NT1 and spz5. Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection. This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites. Also involved in the targeting of other classes of ORN axons. Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS). May be an upstream component of the NF-kappa-B (rel) regulatory cascade.
Gene References into Functions
  1. This study demonistrated that Toll-7 have neurotrophic functions in the Drosophila CNS matching those of DNT1 and DNT2 also pleiotropic functions, maintaining predominantly interneuron survival and regulating motor-axon targeting. PMID: 23892553
  2. Toll-7 is a pattern recognition receptor both in vitro and in adult flies; loss of Toll-7 led to increased vesicular stomatitis virus replication and mortality PMID: 22464169
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Toll-like receptor family
Tissue Specificity
Expressed in the fan-shaped body and the ellipsoid body, which are components of the locomotion center in the CNS (at protein level).
Database Links

KEGG: dme:Dmel_CG8595

STRING: 7227.FBpp0085638

UniGene: Dm.2660

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