Name: TXNDC17 Antibody
Brand: CUSABIO
SKU: CSB-PA025376ZA01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) TXNDC17 Polyclonal antibody
Uniprot No.	Q9BRA2
Target Names	TXNDC17
Alternative Names	TXNDC17 antibody; TXNL5Thioredoxin domain-containing protein 17 antibody; 14 kDa thioredoxin-related protein antibody; TRP14 antibody; Protein 42-9-9 antibody; Thioredoxin-like protein 5 antibody
Raised in	Rabbit
Species Reactivity	Homo sapiens
Immunogen	Recombinant Homo sapiens TXNDC17 protein
Immunogen Species	Homo sapiens (Human)
Conjugate	Non-conjugated
Clonality	Polyclonal
Isotype	IgG
Purification Method	Protein A/G
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA, WB (ensure identification of antigen)
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables	① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee	① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Lead Time	Made-to-order (12-14 weeks)

Target Background

Function (From Uniprot)	Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
Gene References into Functions	found STAT3 could bind promoter region of TXNDC17 (-623 bp to -58 bp relative to the transcription start site (TSS)) for regulating its expression PMID: 26976343 TXNDC17, through participation of BECN1, induces autophagy and consequently results in paclitaxel resistance in ovarian cancer PMID: 25607466 The oxidoreductase activities of TRP14 thereby complement those of Trx1 and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols. PMID: 24778250 TRP14 is a thioredoxin-related protein with roles in tumor necrosis factor-alpha signaling pathways PMID: 14607843 TRP14 is a thioredoxin-related protein of 14 kDa PMID: 14607844 Data report the crystal structure of human thioredoxin-related protein 14 determined at 1.8-angstrom resolution. PMID: 15355959 LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state. PMID: 18579519 Show More Hide All
Subcellular Location	Cytoplasm.
Protein Families	Thioredoxin family
Tissue Specificity	Ubiquitously expressed in cell lines.
Database Links	HGNC: 28218 KEGG: hsa:84817 STRING: 9606.ENSP00000250101 UniGene: Hs.408236

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TXNDC17 Antibody

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Code	CSB-PA025376ZA01HU
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