VPREB1 Antibody

Code CSB-PA025887ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) VPREB1 Polyclonal antibody
Uniprot No.
Target Names
VPREB1
Alternative Names
CD179 antigen like family member A antibody; CD179 antigen-like family member A antibody; CD179a antibody; IGI antibody; IGVPB antibody; Immunoglobulin iota chain antibody; Pre B lymphocyte 1 antibody; pre-B lymphocyte 1 antibody; Protein VPreB1 antibody; V(pre)B protein antibody; VPREB 1 antibody; VPREB antibody; VpreB protein antibody; VPREB_HUMAN antibody; VPREB1 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens VPREB1 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
Gene References into Functions
  1. Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia. PMID: 27611867
  2. VPREB1 focal deletions are common in B-ALL and occur independent of V(D)J light chain recombination. Focal deletions of VPREB1 correlate with decreased expression levels and high-risk patients with focal deletions tend to have poorer overall survival PMID: 23881307
  3. The proportion of the individuals with <2 copies of the VPREB1 gene was significantly higher in the patient group than that in the controls, while that of the individuals with >2 copies was lower in the patient group than that in the controls. PMID: 21144590
  4. The 5' region of the VpreB gene contains a promoter which displays higher relative activity in preB cells compared with cells at other stages or from other lineages. PMID: 11994467
  5. Pre-B cell integrins and their stromal cell ligands together with the pre-B cell receptor and galectin-1 form a homogeneous lattice at the contact area between bone marrow pre-B and stromal cells. PMID: 16818733

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Subcellular Location
Endoplasmic reticulum.
Protein Families
Immunoglobulin superfamily
Tissue Specificity
Only expressed by pre-B-cells.
Database Links

HGNC: 12709

OMIM: 605141

KEGG: hsa:7441

STRING: 9606.ENSP00000385361

UniGene: Hs.247979

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